Publications & Blog

Biomarker Discovery & Validation Biomarker discovery is defined as the process in which biological markers, or “biomarkers” for short, are evaluated and measured. This process begins with defining a biological process and analyzing for different types of biomarkers. These can be prognostic, diagnostic, or predictive to determine treatment efficacy or monitor patient safety. Expanding upon this definition, the World Health Organization defines this term as "almost any measurement reflecting an interaction between a biological system and a potential hazard, which may be chemical, physical, or biological.” Biomarkers are also an integral part of drug development as they help accurately determine drug safety and efficacy. In contemporary medicine, many clinical decisions are based upon laboratory test results. According to the Centers for Disease Control, these tests account for 70% of clinical decisions.

Originally published in Pharmaceutical Research Purpose Dysregulations of key signaling pathways in metabolic syndrome are multifactorial, eventually leading to cardiovascular events. Hyperglycemia in conjunction with dyslipidemia induces insulin resistance and provokes release of proinflammatory cytokines resulting in chronic inflammation, accelerated…

Originally published at Nature Scientific Reports Prediction of the first-in-human dosing regimens is a critical step in drug development and requires accurate quantitation of drug distribution. Traditional in vivo studies used to characterize clinical candidate’s volume of distribution are error-prone,…

Fluoroquinolones (FQs) are a widespread class of broad-spectrum antibiotics prescribed as a first line of defense, and, in some cases, as the only treatment against bacterial infection. However, when administered orally, reduced absorption and bioavailability can occur due to chelation…