BIOiSIM is a first-in-class decision-making engine that can take your toughest questions and generate answers to guide your next steps at any stage of drug development. With the acquisition of Molomics, it will be powered by one of the largest and fastest growing inferential search spaces in existence, encompassing over 1 trillion compounds.
BIOiSIM is a first-in-class decision-making engine that can take your toughest questions and generate answers to guide your next steps at any stage of drug development. With the acquisition of Molomics, it will be powered by one of the largest and fastest growing inferential search spaces in existence, encompassing over 1 trillion compounds.
Originally published in Pharmaceutical Research Purpose Dysregulations of key signaling pathways in metabolic syndrome are multifactorial, eventually leading to cardiovascular events. Hyperglycemia in conjunction with dyslipidemia induces insulin resistance and provokes release of proinflammatory cytokines resulting in chronic inflammation, accelerated…
Originally published in Pharmaceutical Research Purpose Dysregulations of key signaling pathways in metabolic syndrome are multifactorial, eventually leading to cardiovascular events. Hyperglycemia in conjunction with dyslipidemia induces insulin resistance and provokes release of proinflammatory cytokines resulting in chronic inflammation, accelerated…
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Originally published at Nature Scientific Reports Prediction of the first-in-human dosing regimens is a critical step in drug development and requires accurate quantitation of drug distribution. Traditional in vivo studies used to characterize clinical candidate’s volume of distribution are error-prone,…
Originally published at Nature Scientific Reports Prediction of the first-in-human dosing regimens is a critical step in drug development and requires accurate quantitation of drug distribution. Traditional in vivo studies used to characterize clinical candidate’s volume of distribution are error-prone,…
Fluoroquinolones (FQs) are a widespread class of broad-spectrum antibiotics prescribed as a first line of defense, and, in some cases, as the only treatment against bacterial infection. However, when administered orally, reduced absorption and bioavailability can occur due to chelation…
Fluoroquinolones (FQs) are a widespread class of broad-spectrum antibiotics prescribed as a first line of defense, and, in some cases, as the only treatment against bacterial infection. However, when administered orally, reduced absorption and bioavailability can occur due to chelation…
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